Function and biological activities of the autotaxin-LPA axis / 生理学报
Acta Physiologica Sinica
;
(6): 601-610, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-335949
ABSTRACT
Autotaxin (ATX), a member of nucleotide pyrophosphatase/phosphodiesterase (NPP) family, is also named as phosphodiesterase Iα (PD-Iα) or NPP2. ATX is the unique member among the NPPs that can function as a lysophospholipase D (lysoPLD), converting lysophosphatidylcholine into lysophosphatidic acid (LPA). LPA acts on specific G-protein-coupled receptors to elicit a wide range of cellular response, including cell proliferation, cell migration and cell contraction, etc. As the major LPA-producing phospholipase, many ATX's features and functions are dependent on the production of LPA. ATX and LPA together form the ATX-LPA functional axis. The present review summarizes the current progress in function and biological activities of ATX-LPA axis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Phospholipases
/
Physiology
/
Lysophospholipids
/
Lysophosphatidylcholines
/
Cell Movement
/
Phosphoric Diester Hydrolases
/
Receptors, G-Protein-Coupled
/
Cell Proliferation
/
Metabolism
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2011
Type:
Article
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