Detection of serum autoantibodies to melanocyte and correlation between melanoma antigen recognized by T-cells and vitiligo in children / 南方医科大学学报
Journal of Southern Medical University
;
(12): 2107-2111, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-336009
ABSTRACT
<p><b>OBJECTIVE</b>To detect the serum levels of melanocyte antibodies and explore the relation between melanoma antigen recognized by T-cells (MART-1) and vitiligo in children.</p><p><b>METHODS</b>The serum samples were collected from children with vitiligo to test the autoantibodies, and divided into low- and high-titer group according to the test results. Melanocytes were incubated with the serum samples, and the changes of melanocyte surface antigen were evaluated using specific MART-1 antibody.</p><p><b>RESULTS</b>The serum melanocyte antibody levels in children with vitiligo were significantly higher than those in normal subjects. The expression level of melanocyte surface antigen MART-1 increased obviously after incubation of the melanocyte with high antibody titer serum samples, and MART-1 was found to specifically bind to specific MART-1 antibody.</p><p><b>CONCLUSION</b>Melanocytes MART-1 may correlate to the autoimmune mechanism in children with vitiligo.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Autoantibodies
/
Vitiligo
/
Blood
/
Enzyme-Linked Immunosorbent Assay
/
T-Lymphocytes
/
Allergy and Immunology
/
MART-1 Antigen
/
Melanocytes
Type of study:
Diagnostic study
Limits:
Adolescent
/
Child
/
Child, preschool
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2009
Type:
Article
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