A comparative study of diffusion-weighted magnetic resonance imaging and pathological findings of liver fibrosis in rabbits / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1965-1968, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-336045
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the alteration of apparent diffusion coefficient (ADC) in diffusion-weighted MR imaging (MR-DWI) of liver fibrosis and its pathological basis in rabbits.</p><p><b>METHODS</b>Five rabbits in the control group and 22 with experimental liver fibrosis induced by transperitoneal injection of carbon tetrachloride (CCl4) were examined with MR-DWI. Diffusion-weighted SE EPI sequence with a relatively high b factor (b=600 s/mm2) was used to measure the ADC. The mean values of ADC were compared among the rabbits in different stages of liver fibrosis and analyzed in relation to the pathological findings.</p><p><b>RESULTS</b>The mean ADC value decreased significantly with increased severity of liver fibrosis (P<0.05). Pathologically, the amount and extension of fibrotic matrix increased, and the hepatic necroinflammation worsened with the progression of the liver fibrosis.</p><p><b>CONCLUSION</b>The ADC value decreases with the progression of liver fibrosis possibly as the result of water diffusion limitation due to increased fibrous tissue in the liver and abnormal water diffusion within the intracellular and extracellular spaces.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Carbon Tetrachloride
/
Magnetic Resonance Imaging
/
Random Allocation
/
Diagnosis
/
Toxicity
/
Liver Cirrhosis
/
Methods
Type of study:
Diagnostic study
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2009
Type:
Article
Similar
MEDLINE
...
LILACS
LIS