Antineoplastic effect of koumine in mice bearing H22 solid tumor / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1851-1852, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-336067
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the antitumor effects of koumine in mice bearing H22 solid tumor and its effect on the immune system of the mice.</p><p><b>METHODS</b>The changes in spleen and tumor weights and blood cell count were observed after koumine treatment in BALB/c athymic mice bearing H22 solid tumor, using normal saline solution and 5-Fu as the controls.</p><p><b>RESULTS</b>Koumine significantly inhibited the tumor growth in a dose-dependent manner. The spleen index and blood cell counts in koumine group showed no significant differences from those in the saline control group, but higher than those in 5-Fu group.</p><p><b>CONCLUSION</b>Koumine can significantly inhibit the growth of H22 solid tumor without obvious inhibitory effect on the immune system in mice.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Chemistry
/
Indole Alkaloids
/
Gelsemium
/
Therapeutic Uses
/
Drug Therapy
/
Allergy and Immunology
/
Liver Neoplasms, Experimental
/
Phytotherapy
/
Mice, Inbred BALB C
/
Mice, Nude
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2009
Type:
Article
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