Changes of peripheral blood chromosomal centromere aberration in patients with cytomegalovirus infection after anti-viral treatment / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1846-1847, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-336069
ABSTRACT
<p><b>OBJECTIVE</b>To study the changes of peripheral blood chromosomal centromere aberration in patents with cytomegalovirus (CMV) infection after anti-viral treatment.</p><p><b>METHODS</b>Sixty-two patients with early spontaneous abortion and CMV infection analyzed for their peripheral blood chromosomal centromere using simultaneous silver staining before and after anti-viral treatment.</p><p><b>RESULTS</b>The patients with CMV infection had high rate of centromere aberration, which was decreased significantly after anti-viral treatment (P<0.0001).</p><p><b>CONCLUSION</b>CMV infection is a risk factor for peripheral blood chromosomal centrimere aberration. Anti-viral treatment can decrease the rate of centrimere aberration aberration. Detection of peripheral blood chromosomal centrimere aberration allows the assessment of the severity of infection and the condition after treatment.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Antiviral Agents
/
Pregnancy Complications, Infectious
/
Blood
/
Abortion, Spontaneous
/
Centromere
/
Chromosome Aberrations
/
Cytomegalovirus Infections
/
Therapeutic Uses
/
Drug Therapy
/
Genetics
Type of study:
Risk factors
Limits:
Adult
/
Female
/
Humans
/
Pregnancy
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2009
Type:
Article
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