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Expressions of receptor-interacting protein and caspase-8 in oral squamous cell carcinoma and oral precancerous lesions / 南方医科大学学报
Journal of Southern Medical University ; (12): 1802-1805, 2009.
Article in Chinese | WPRIM | ID: wpr-336081
ABSTRACT
<p><b>OBJECTIVE</b>To detect the expressions of receptor-interacting protein (RIP) and caspase-8 and investigate their roles in oral squamous cell carcinoma (OSCC) and oral precancerous lesions.</p><p><b>METHODS</b>SABC immunohistochemical methods were used to detect the expressions of RIP and caspase-8 in 22 specimens of OSCC, 14 specimens of oral lichen planus (OLP), 14 specimens of oral leukoplakia (OLK) and 10 specimens of normal oral mucosa (NOM).</p><p><b>RESULTS</b>The rate of weak or negative expression of RIP in normal mucosa was 50% (5/10). The rates of weak and positive expression of RIP in OLP, OLK and OSCC were 75% (36/50), and the rate of positive and strong expression of RIP was 63.7% (14/22) in OSCC, significantly higher that in the others groups (P<0.05). The rates of weak, positive and strong positive expression of caspase-8 in NOM, OLP, OLK and OSCC were 80% (8/10), 100% (14/14), 85.7% (12/14), and 100% (22/22), respectively.</p><p><b>CONCLUSION</b>Both RIP and caspase-8 may play important roles in the occurrence and progression of OSCC and oral precancerous lesions.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Precancerous Conditions / Mouth Neoplasms / Immunohistochemistry / Carcinoma, Squamous Cell / Caspase 8 / Receptor-Interacting Protein Serine-Threonine Kinases / Metabolism Limits: Female / Humans / Male Language: Chinese Journal: Journal of Southern Medical University Year: 2009 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Precancerous Conditions / Mouth Neoplasms / Immunohistochemistry / Carcinoma, Squamous Cell / Caspase 8 / Receptor-Interacting Protein Serine-Threonine Kinases / Metabolism Limits: Female / Humans / Male Language: Chinese Journal: Journal of Southern Medical University Year: 2009 Type: Article