Therapeutic effects of amiodarone and metoprolol on chronic heart failure complicated by ventricular arrhythmia / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1240-1242, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-336101
ABSTRACT
<p><b>OBJECTIVE</b>To explore the therapeutic effects of amiodarone and metoprolol, either alone or in combination, on chronic heart failure (CHF) complicated by ventricular arrhythmia.</p><p><b>METHODS</b>A total of 110 NYHA class II-III patients with CHF complicated by ventricular arrhythmia were randomly divided into amiodarone group, metoprolol group and amiodarone + metoprolol group. The therapeutic effects was evaluated at the end of the 1-year follow-up.</p><p><b>RESULTS</b>Amiodarone, metoprolol and their combination produced statistically different therapeutic effects (P<0.05). Compared with amiodarone and metoprolol used alone, amiodarone combined with metoprolol resulted in significant cardiac function improvement (P<0.05) and ventricular arrhythmia control (P<0.01). During the 1-year follow-up, the readmission rate and cardiac event rate in the amiodarone + metoprolol group were significantly lower than those in amiodarone group (P<0.01) and metoprolol group (P<0.05). The adverse reaction rates in the 3 groups were similar (P>0.05).</p><p><b>CONCLUSION</b>The combination of amiodarone and metoprolol produces better effect than amiodarone or metoprolol alone in the treatment of CHF complicated by ventricular arrhythmia.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Chronic Disease
/
Treatment Outcome
/
Tachycardia, Ventricular
/
Adrenergic beta-Antagonists
/
Ventricular Premature Complexes
/
Therapeutic Uses
/
Drug Therapy
/
Drug Therapy, Combination
/
Heart Failure
/
Amiodarone
Limits:
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2009
Type:
Article
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