Expression of human beta-defensin after endoscopic sinus surgery for chronic sinusitis / 南方医科大学学报
Journal of Southern Medical University
; (12): 1580-1583, 2010.
Article
in Zh
| WPRIM
| ID: wpr-336137
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To observe the expressions of human beta-defensin 1 and 2 (hBD-1 and hBD-2) in nasal mucosa before and after the endoscopic sinus surgery and investigate the effects of hBD-1 and hBD-2 on the healing process after the surgery.</p><p><b>METHODS</b>The patients undergoing endoscopic sinus surgery for chronic sinusitis were divided into 3 groups according to the response to the surgery, namely cured group, response group and non-response group. With those from healthy control subjects as the control, nasal mucosa samples were collected from the patients at 1 week, 2 weeks, 1 month, 3 months and 6 months after the surgery for detection of hBD-1 and hBD-2 mRNA and protein expressions by RT-PCR and Western blotting.</p><p><b>RESULTS</b>hBD-1 and hBD-2 were expressed in both normal and chronic sinusitis mucosa, but the expression levels varied significantly between the individuals. The expression levels of hBD-2 was significantly correlated to the patients' response to the surgical treatment (P<0.05). hBD-1 showed slight differences between the individuals, but was not associated with the patients' prognosis.</p><p><b>CONCLUSION</b>The expressions of hBD-2 mRNA and protein are significantly increased in patients with good response to endoscopic sinus surgery for chronic sinusitis, suggesting the value of hBD-2 as an indicator of the patients' prognosis.</p>
Full text:
1
Index:
WPRIM
Main subject:
Postoperative Period
/
Prognosis
/
Sinusitis
/
General Surgery
/
RNA, Messenger
/
Case-Control Studies
/
Chronic Disease
/
Beta-Defensins
/
Endoscopy
/
Genetics
Type of study:
Observational_studies
/
Prognostic_studies
/
Risk_factors_studies
Limits:
Humans
Language:
Zh
Journal:
Journal of Southern Medical University
Year:
2010
Type:
Article