Preoperative chemoradiotherapy followed by local excision in clinical T2N0 rectal cancer
Radiation Oncology Journal
;
: 177-185, 2016.
Article
in English
| WPRIM
| ID: wpr-33617
ABSTRACT
PURPOSE:
To investigate whether preoperative chemoradiotherapy (PCRT) followed by local excision (LE) is feasible approach in clinical T2N0 rectal cancer patients. MATERIALS ANDMETHODS:
Patients who received PCRT and LE because of clinical T2 rectal cancer within 7 cm from anal verge between January 2006 and June 2014 were retrospectively analyzed. LE was performed in case of a good clinical response after PCRT. Patients’ characteristics, treatment record, tumor recurrence, and treatment-related complications were reviewed at a median follow-up of 49 months.RESULTS:
All patients received transanal excision or transanal minimally invasive surgery. Of 34 patients, 19 patients (55.9%) presented pathologic complete response (pCR). The 3-year local recurrence-free survival and disease free-survival were 100.0% and 97.1%, respectively. There was no recurrence among the patients with pCR. Except for 1 case of grade 4 enterovesical fistula, all other late complications were mild and self-limiting.CONCLUSION:
PCRT followed by an LE might be feasible as an alternative to total mesorectal excision in good responders with clinical T2N0 distal rectal cancer.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Radiotherapy
/
Rectal Neoplasms
/
Recurrence
/
Polymerase Chain Reaction
/
Retrospective Studies
/
Follow-Up Studies
/
Minimally Invasive Surgical Procedures
/
Neoadjuvant Therapy
/
Chemoradiotherapy
/
Fistula
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Radiation Oncology Journal
Year:
2016
Type:
Article
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