The response of thrombosis in the portal vein or hepatic vein in hepatocellular carcinoma to radiation therapy
Radiation Oncology Journal
;
: 168-176, 2016.
Article
in English
| WPRIM
| ID: wpr-33618
ABSTRACT
PURPOSE:
The purpose of current study is to evaluate the response of the patients with portal vein thrombosis (PVT) or hepatic vein thrombosis (HVT) in hepatocellular carcinoma (HCC) treated with three-dimensional conformal radiation therapy (3D-CRT). In addition, survival of patients and potential prognostic factors of the survival was evaluated. MATERIALS ANDMETHODS:
Forty-seven patients with PVT or HVT in HCC, referred to our department for radiotherapy, were retrospectively reviewed. For 3D-CRT plans, a gross tumor volume (GTV) was defined as a hypodense filling defect area in the portal vein (PV) or hepatic vein (HV). Survival of patients, and response to radiation therapy (RT) were analyzed. Potential prognostic factors for survival and response to RT were evaluated.RESULTS:
The median survival time of 47 patients was 8 months, with 1-year survival rate of 15% and response rate of 40%. Changes in Child-Pugh score, response to RT, Eastern cooperative oncology group performance status (ECOG PS), hepatitis C antibody (HCVAb) positivity, and additional post RT treatment were statistically significant prognostic factors for survival in univariate analysis (p = 0.000, p = 0.018, p = 0.000, p = 0.013, and p = 0.047, respectively). Of these factors, changes in Child-Pugh score, and response to RT were significant for patients’ prognosis in multivariate analysis (p = 0.001 and p = 0.035, respectively).CONCLUSION:
RT could constitute a reasonable treatment option for patients with PVT or HVT in HCC with acceptable toxicity. Changes in Child-Pugh score, and response to RT were statistically significant factors of survival of patients.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Portal Vein
/
Prognosis
/
Radiotherapy
/
Thrombosis
/
Multivariate Analysis
/
Survival Rate
/
Retrospective Studies
/
Hepatitis C
/
Carcinoma, Hepatocellular
/
Venous Thrombosis
Type of study:
Observational study
/
Prognostic study
Limits:
Humans
Language:
English
Journal:
Radiation Oncology Journal
Year:
2016
Type:
Article
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