An analysis of the characteristics and etiology of hand, foot and mouth disease in a Guangzhou sentinel hospital from May to December, 2008 / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1333-1335, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-336186
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the characteristics and etiology of hand, foot and mouth disease (HFMD) in a sentinel hospital of Guangzhou.</p><p><b>METHODS</b>The epidemiological data and clinical specimens were collected from May to December, 2008 for virological investigations (viral isolation, RT-PCR and molecular identification) and phylogenetic analysis.</p><p><b>RESULTS</b>A total of 309 clinical cases were reported, and the incidence was the highest in 2-4-year-old children, among whom only 15 developed complications, with human enterovirus 71 (HEV71) as the main pathogen (64.7%). Phylogenetic analysis indicated that ten Guangzhou EV71 isolates belonged to Cluster C4a.</p><p><b>CONCLUSION</b>HFMD is an important infectious disease in children resulting from infections by HEV71 as the main pathogen in 2008, and the Guangzhou C4a strains co-evolved with the isolates from other provinces in China and the neighboring countries.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Virology
/
China
/
Epidemiology
/
Incidence
/
Reverse Transcriptase Polymerase Chain Reaction
/
Enterovirus A, Human
/
Hand, Foot and Mouth Disease
Type of study:
Etiology study
/
Incidence study
/
Prognostic study
Limits:
Child, preschool
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2010
Type:
Article
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