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Acute phase reaction of different macromolecule vascular grafts healing in rat muscle / 生物工程学报
Chinese Journal of Biotechnology ; (12): 79-84, 2010.
Article in Chinese | WPRIM | ID: wpr-336258
ABSTRACT
To find out which biomaterial had the best biocompatibility, we compared the acute phase reaction of common biomaterials preparing for vascular grafts with the material of polyurethane modified by silk fibroin (SF-PU(11)). After transplanted the materials of dacron, polyterafluoroethylene (e-PTFE), polyurethane (PU), SF-PU(11) in rat muscle for one week, we studied the influence of different biomaterials on the histocompatibility by using rat acute toxicity test, test of local reaction in muscle, tissue section staining, WBC and PLT count. As a result, dacron had the worst histocompatibility. The other biomaterials had slight local inflammatory reaction. The WBC and PLT was nearly the same with the blank except dacron. e-PTFE, pure PU and SF-PU(11) had the better histocompatibility than traditional dacron. Especially SF-PU(11) had the best histocompatibility. Because of the better physical properties and histocompatibility of SF-PU( 11), the prospect of preparing small-diameter vascular grafts with SF-PU was cheerful.
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Polyurethanes / Prosthesis Design / Biocompatible Materials / Materials Testing / Blood Vessel Prosthesis / Random Allocation / Chemistry / Acute-Phase Reaction / Rats, Sprague-Dawley Limits: Animals Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2010 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Physiology / Polyurethanes / Prosthesis Design / Biocompatible Materials / Materials Testing / Blood Vessel Prosthesis / Random Allocation / Chemistry / Acute-Phase Reaction / Rats, Sprague-Dawley Limits: Animals Language: Chinese Journal: Chinese Journal of Biotechnology Year: 2010 Type: Article