Ataxia-telangiectasia mutated gene and breast cancer susceptibility / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 9-15, 2010.
Article
in Chinese
| WPRIM
| ID: wpr-336268
ABSTRACT
Breast cancer is bound up with the environment. As a consequence of DNA damage induced by environmental carcinogens, a number of sophisticated sensing and transduction systems are initiated and the signal is conveyed simultaneously to multiple effectors. This process ultimately results in cancer. The protein kinase Ataxia-telangiectasia mutated (ATM) that encoded by ATM gene is the master regulator of DNA damage response. In this consecutive reaction, the protein kinase ATM responds to the DNA damage by phosphorylating a variety of downstream substrates, which plays an important role in the inhibition of the development of breast cancer. After ATM gene mutate, DNA damaged could not be accurately repaired and finally accelerates breast cancer transformation and proliferation. With the further research of ATM gene structure, function and breast cancer susceptibility, the extensive attention is paid to the relationship between ATM gene and breast cancer susceptibility. We reviewed the research advances in breast cancer susceptibility in several aspects of ATM gene, including mutation, polymorphism and methylation.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Polymorphism, Genetic
/
DNA Damage
/
Breast Neoplasms
/
Protein Serine-Threonine Kinases
/
Cell Cycle Proteins
/
DNA Methylation
/
Genetic Predisposition to Disease
/
Tumor Suppressor Proteins
/
DNA-Binding Proteins
/
Ataxia Telangiectasia Mutated Proteins
Limits:
Female
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2010
Type:
Article
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