A Clinical Study on Patients with Chronic Lymphocytic Leukemia / 대한암학회지
Journal of the Korean Cancer Association
;
: 1106-1113, 1997.
Article
in Korean
| WPRIM
| ID: wpr-33637
ABSTRACT
PURPOSE:
Chronic lymphocytic leukemia (CLL) is the most common form of leukemia in western countries but it has been reported rarely in Korea. The purpose of this study was to evaluate the clinical characteristics, treatment responses and prognosis of the patients with CLL. MATERIALS ANDMETHODS:
We retrospectively reviewed the medical records of 17 patients with CLL diagnosed at the Catholic University of Taegu-Hyosung & Kyungpook National University Hospital from Jan. 1986 to Mar. 1996.RESULTS:
There were 9 males and 8 females and the mean age was 55 years. The majority of patients had systemic symptoms (77%) and advanced clinical stage (Binet stage C, 70%) at the time of diagnosis. The bone marrow histology was reviewed in 13 cases and patients were subdivided into those with a diffuse (9cases) and nondiffuse (4cases) pattern of bone marrow histology. In patients with advanced clinical stage, diffuse pattern was predominated and showed poor survival. 14 patients were treated with chlorambucil/steroid or combination chemotherapy. Among the 13 evaluable patients, 1 (8%) achieved a complete response and 7 (54%) achieved partial responses, and median survival duration was 18months. 11 patients died after 2~18 months of follow-up and infection was the main cause of death.CONCLUSION:
Poor prognostic factors, such as high blood lymphocyte counts, diffuse bone marrow involvement pattern & advanced clinical stage, are common in our patients at presentation & showed poor survival.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prognosis
/
Bone Marrow
/
Leukemia, Lymphocytic, Chronic, B-Cell
/
Leukemia
/
Medical Records
/
Retrospective Studies
/
Follow-Up Studies
/
Cause of Death
/
Lymphocyte Count
/
Diagnosis
Type of study:
Diagnostic study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
Korean
Journal:
Journal of the Korean Cancer Association
Year:
1997
Type:
Article
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