Expression of Plexin A1 in gastric carcinoma and its relationship with tumor angiogenesis and proliferation / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 265-268, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-336461
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of Plexin A1 in gastric cancer(GC) and its relationship with angiogenesis and proliferation of GC.</p><p><b>METHODS</b>Plexin A1 mRNA expression in 20 cases of GC specimens and matched resected normal gastric tissue were examined by RT-PCR. Plexin A1, Ki-67, vascular endothelial growth factor(VEGF) protein expression and microvessel density (MVD) in 50 cases of GC specimens and 20 cases of normal gastric mucosa were detected by immunohistochemistry.</p><p><b>RESULTS</b>RT-PCR showed that the expression of Plexin A1 in GC was significantly higher than that in normal gastric mucosa(0.71 +/- 0.37 vs 0.60 +/- 0.25, P < 0.05). MVD within tumor tissue increased significantly with Plexin A1 mRNA expression(r=0.8736, P < 0.01) and Plexin A1 protein expression (P < 0.01). The Plexin A1 expression was positively correlated with the proliferation index (Ki-67) of cancer cells (r=0.4851, P < 0.01). However, the Plexin A1 expression level had no relationship with the VEGF expression level.</p><p><b>CONCLUSION</b>Plexin A1 plays an important role in the occurrence and development of GC. Plexin A1 may regulate angiogenesis, and promote the proliferation of GC cells.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Stomach Neoplasms
/
Receptors, Cell Surface
/
Ki-67 Antigen
/
Vascular Endothelial Growth Factor A
/
Cell Proliferation
/
Metabolism
/
Neovascularization, Pathologic
/
Nerve Tissue Proteins
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Gastrointestinal Surgery
Year:
2007
Type:
Article
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