Risk factors for leukopenia in patients with gastrointestinal fistula / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 3433-3437, 2010.
Article
in English
| WPRIM
| ID: wpr-336607
ABSTRACT
<p><b>BACKGROUND</b>White blood cell count is an important index to the outcome of patients. In hospital, leukopenia is accompanied by high mortality, morbidity and treatment costs. However, in infectious diseases, the reasons responsible for leucopenia was not well elucidated. We investigated patients with gastrointestinal fistula to find risk factors for leukopenia.</p><p><b>METHODS</b>A prospective case control investigation was carried out in the Gastrointestinal Fistula Center, General Surgical Institute of Jinling Hospital. Cases included gastrointestinal fistula patients with leukopenia (n = 98) and controls composed of gastrointestinal fistula patients with normal white blood cell count (n = 78). The two groups were compared for risk factors of leucopenia by statistical analysis.</p><p><b>RESULTS</b>Factors associated with an increased risk for leukopenia included bacterial infection (25.5%) and hypoalbuminaemia (61.2%). Multivariable Logistic regression analysis identified bacterial infection (80%), urinary catheter (70%) and central vein catheter (60%) as the independent determinants for mortality in cases.</p><p><b>CONCLUSIONS</b>In patients with gastrointestinal fistula, two independent factors for leukopenia and three significant predictors of mortality were elucidated. We suggest that clinicians give patients more supportive management and apply prevention strategies to treat and prevent leukopenia.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Bacterial Infections
/
Catheterization, Central Venous
/
Urinary Catheterization
/
Case-Control Studies
/
Logistic Models
/
Prospective Studies
/
Risk Factors
/
Mortality
/
Gastric Fistula
/
Intestinal Fistula
Type of study:
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Medical Journal
Year:
2010
Type:
Article
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