Determination of enantiomeric impurity in levocetirizine tablets by capillary electrophoresis / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 150-154, 2014.
Article
in Chinese
| WPRIM
| ID: wpr-336727
ABSTRACT
<p><b>OBJECTIVE</b>To determine enantiomeric impurity in levocetirizine tablets by using capillary electrophoresis.</p><p><b>METHODS</b>The effects of pH and the concentrations of sulfated-Β-cyclodextrin (S-Β-CD) and buffer salt on chiral resolution were examined with S-Β-CD as chiral selector.</p><p><b>RESULTS</b>A good enantioseparation of cetirizine was achieved with 30 mmol/L NaH2PO4 buffer solution (pH 7.0) containing 20 g/L of S-Β-CD.</p><p><b>CONCLUSION</b>The method developed in the study is sensitive and reliable for determination of enantiomeric impurity in levocetirizine tablets.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stereoisomerism
/
Tablets
/
Cetirizine
/
Electrophoresis, Capillary
/
Methods
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2014
Type:
Article
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