Effect of Helicobacter pylori infection on platelet activation and coagulation function in patients with acute cerebral infarction / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 547-552, 2012.
Article
in Zh
| WPRIM
| ID: wpr-336754
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the effect of Helicobacter pylori (Hp) on platelet activation and coagulation function in patients with acute cerebral infarction.</p><p><b>METHODS</b>Sixty-six patients with acute cerebral infarction and 50 health individuals were enrolled in the study. Hp antibody,expression of CD62p on platelets and clotting indexes were measured and compared between two groups.</p><p><b>RESULTS</b>The positive rate of Hp-IgG and Hp-CagA in cerebral infarction patients were higher than that in controls (P<0.05). The positive rate of CD62p in patients with positive Hp-IgG and Hp-CagA was significantly higher than that in negative patients and also controls (P<0.05). The APTT and TT were lower and FIB was higher in patients with positive Hp antibody than those in patients with negative Hp antibody (P<0.05),but there was no difference in PT,PTR and INR (P>0.05).</p><p><b>CONCLUSION</b>Hp infection can activate platelets and affect coagulation function,which may be involved in the development of cerebral infarction.</p>
Full text:
1
Index:
WPRIM
Main subject:
Bacterial Proteins
/
Virulence
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Blood
/
Blood Coagulation
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Immunoglobulin G
/
Case-Control Studies
/
Platelet Activation
/
Cerebral Infarction
/
Helicobacter pylori
/
Helicobacter Infections
Type of study:
Observational_studies
Limits:
Adult
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Aged
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Female
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Humans
/
Male
Language:
Zh
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2012
Type:
Article