Advances on relationship between insulin receptor substrate-1 and insulin resistance in liver cirrhosis / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 339-344, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-336786
ABSTRACT
Liver cirrhosis (LC) and insulin resistance (IR) are closely correlated, clinically presenting hyperglycemia, hyperinsulinism, hyperlipidemia and high cytokines levels, however, the underlying mechanism is not completely clear. Recent reports show that insulin receptor substrate-1 (IRS-1) is associated with IR in LC. IRS-1 plays a pivotal role on insulin signal transduction; it changes insulin signaling by up-or down-regulating of protein presentation, post-translational modification and subcellular localization of proteins, particularly in phosphorylation/dephosphorylation of post-translational modification. Furthermore, LC with different etiology may have different mechanism of IRS-1 effect on IR.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Insulin Resistance
/
Insulin Receptor Substrate Proteins
/
Insulin
/
Liver Cirrhosis
/
Metabolism
Limits:
Humans
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2012
Type:
Article
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