Characteristic of microglial activation of hippocampus in experimental epileptic rats / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
;
(6): 310-314, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-336791
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the characteristics of microglial activation of hippocampus in experimental epileptic rats.</p><p><b>METHODS</b>Morphological changes and proliferation of OX-42 positive cells were compared at different time points after status of epilepticus (SE) in lithium-pilocarpine induced epileptic rats.</p><p><b>RESULTS</b>OX-42 positive cells were activated after SE, which increased to a peak at 3-7 d and in a relatively stable state at 7-14 d; then gradually decreased after 14d and returned to slightly higher level than previously at 21 d.</p><p><b>CONCLUSION</b>Inflammatory injury, microglial activation and cell proliferation are closely related after seizures, microglial activation may be an important mechanism in the inflammatory injury of epilepsy.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Status Epilepticus
/
Rats, Sprague-Dawley
/
Microglia
/
Cell Biology
/
Cell Proliferation
/
Disease Models, Animal
/
Hippocampus
Type of study:
Prognostic study
Limits:
Animals
Language:
Chinese
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2012
Type:
Article
Similar
MEDLINE
...
LILACS
LIS