Serum sCD44v6 and sE-cadherin levels in patients with esophageal squamous cell carcinoma / 浙江大学学报·医学版
Journal of Zhejiang University. Medical sciences
; (6): 305-309, 2012.
Article
in Zh
| WPRIM
| ID: wpr-336792
Responsible library:
WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the serum levels of sCD44v6 and sE-cadherin (sE-cad) in patients with esophageal squamous cell carcinoma.</p><p><b>METHODS</b>The serum samples were collected from 65 cases of esophageal squamous cell carcinoma, 32 cases of erosive esophagitis and 35 healthy subjects. Serum sCD44v6 and sE-cad levels were measured by enzyme linked immunosorbent assay (ELISA).</p><p><b>RESULTS</b>The mean levels of serum sCD44v6 and sE-cad in esophageal squamous cell carcinoma patients were significantly higher than those of erosive esophagitis patients and normal controls (both P<0.05). There was no significant difference in serum sCD44v6 and sE-cad levels between erosive esophagitis patients normal controls (P=0.566 and P=0.708, respectively). Serum sCD44v6 and sE-cad levels of esophageal cancer patients were not correlated with their clinicopathological features. Serum sCD44v6 level is not correlated with sE-cad level in squamous cell carcinoma patients(P=0.651).</p><p><b>CONCLUSION</b>Serum sCD44v6 and sE-cad might be a potential marker for screening of esophageal squamous cell carcinoma.</p>
Full text:
1
Index:
WPRIM
Main subject:
Pathology
/
Blood
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Esophageal Neoplasms
/
Carcinoma, Squamous Cell
/
Cadherins
/
Case-Control Studies
/
Hyaluronan Receptors
Type of study:
Observational_studies
Limits:
Adult
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Aged
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Aged80
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Female
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Humans
/
Male
Language:
Zh
Journal:
Journal of Zhejiang University. Medical sciences
Year:
2012
Type:
Article