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Clinical significance of HLA-DRB1 and HLA-DPB1 gene polymorphisms in cirrhosis patients / 中华肝脏病杂志
Chinese Journal of Hepatology ; (12): 744-746, 2014.
Article in Chinese | WPRIM | ID: wpr-337107
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the genetic association between cirrhosis and polymorphisms in the genes encoding major histocompatibility complex, class II (HLA)-DR beta 1 (DRB1) and HLA-DP beta 1 (DPB1).</p><p><b>METHODS</b>A population of 168 parent/offspring trios, in which the proband had a diagnosis of hepatitis B virus infection with clinical signs of cirrhosis.The HLA-DRB1 and DPB 1 gene polymorphisms of rs24755213 and rs202176660 were detected by PCR and single nucleotide polymorphism (SNP) genotyping.Correlation analysis and haplotype relative risk analysis were carried out.</p><p><b>RESULTS</b>A/G genotypes were detected in rs24755213 of HLA-DRB1 and C/T genotypes were detected in rs202176660 of DPB1.The rs24755213 allele was associated with cirrhosis (P=0.014), with the G allele identified as a protective factor (Z=-2.33) and the A allele identified as a hazard factor (Z=2.33).The rs202176660 allele was also associated with cirrhosis (P =0.026), with the T allele identified as a protective factor (Z=-2.06) and the C allele identified as a hazard factor (Z=2.06).The haplotypes of G/T and A/C in rs24755213 and rs202176660 respectively were associated with cirrhosis (P =0.037 and 0.002, Z=-2.12 and 2.09 respectively).</p><p><b>CONCLUSION</b>In this group of Chinese patients with hepatitis B virus-related cirrhosis, polymorphisms in the HLA-DRB 1 and DPB1 genes were associated with cimhosis.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Polymorphism, Genetic / Haplotypes / Alleles / HLA-DP beta-Chains / HLA-DRB1 Chains / Genetics / Genotype / Liver Cirrhosis Type of study: Etiology study / Prognostic study Limits: Humans Language: Chinese Journal: Chinese Journal of Hepatology Year: 2014 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Polymorphism, Genetic / Haplotypes / Alleles / HLA-DP beta-Chains / HLA-DRB1 Chains / Genetics / Genotype / Liver Cirrhosis Type of study: Etiology study / Prognostic study Limits: Humans Language: Chinese Journal: Chinese Journal of Hepatology Year: 2014 Type: Article