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Analgesic effect of interleukin-2 in mouse models of spared nerve injury / 南方医科大学学报
Journal of Southern Medical University ; (12): 1180-1182, 2007.
Article in Chinese | WPRIM | ID: wpr-337301
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the analgesic effect of interleukin-2 (IL-2) in mice with spared nerve injury (SNI).</p><p><b>METHOD</b>IL-2 was intraperitoneally injected in mice with induced SNI, and von Frey Filaments test and cold plate test were carried out to accesses the analgesic effects of IL-2 and the effect of naloxone in antagonizing the effects of IL-2.</p><p><b>RESULTS</b>IL-2 produced analgesic effects against hyperalgesia and allodynia in mouse models of SNI, and the effect of IL-2 lasted for more than 24 h, showing a double-peak pattern in its action with the two peaks occurring at 30 and 105 min, respectively. The effect of IL-2 could be significantly antagonized by naloxone.</p><p><b>CONCLUSIONS</b>IL-2 has long-lasting analgesic effects in mouse models of SNI model, showing a double-peak pattern of its action. The analgesic effect of IL-2 is probably mediated by opiate receptor.</p>
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Interleukin-2 / Trauma, Nervous System / Therapeutic Uses / Disease Models, Animal / Dose-Response Relationship, Drug / Drug Therapy / Hyperalgesia / Analgesics / Mice, Inbred BALB C Type of study: Prognostic study Limits: Animals / Humans / Male Language: Chinese Journal: Journal of Southern Medical University Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Interleukin-2 / Trauma, Nervous System / Therapeutic Uses / Disease Models, Animal / Dose-Response Relationship, Drug / Drug Therapy / Hyperalgesia / Analgesics / Mice, Inbred BALB C Type of study: Prognostic study Limits: Animals / Humans / Male Language: Chinese Journal: Journal of Southern Medical University Year: 2007 Type: Article