Effect of p53 gene knockout on cell migration / 南方医科大学学报
Journal of Southern Medical University
;
(12): 1132-1135, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-337313
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the role of p53 gene in serum-induced cell migration.</p><p><b>METHODS</b>The effects of p53 knockout on serum-induced formation of lamellipodia and cell migration were observed using Transwell cell migration system.</p><p><b>RESULTS</b>p53(+/+) cells developed lamellipodia upon serum stimulation and showed enhanced activity of cell migration, but these effects were not observed in p53 knockout cells after serum stimulation.</p><p><b>CONCLUSION</b>p53 plays a role in serum-induced cell migration.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pseudopodia
/
Cell Line
/
Cell Movement
/
Gene Expression Regulation
/
Tumor Suppressor Protein p53
/
Serum
/
Gene Knockout Techniques
/
Genetics
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2007
Type:
Article
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