Expression of chemokine receptor CXCR3 mRNA in patients with atopic dermatitis / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the role of chemokine receptor CXCR3 in patients with atopic dermatitis.</p><p><b>METHODS</b>The expression of CXCR3 mRNA was measured by fluorescent quantitative polymerase chain reaction, and the relationship between CXCR3 mRNA expression and the disease severity (graded according to SCORAD index system) was assessed by correlation analysis.</p><p><b>RESULTS</b>CXCR3 mRNA expression was significantly higher in patients with atopic dermatitis than in healthy control subjects (P7lt;0.01), and showed obvious positive correlation with SCORAD index system.</p><p><b>CONCLUSION</b>These data suggest an important role of CXCR3 in the development and progression of atopic dermatitis.</p>