Changes of pulmonary artery protein kinase C activity in rats with chronic inflammatory pulmonary hypertension / 南方医科大学学报

ABSTRACT

<p><b>OBJECTIVE</b>To observe the changes in pulmonary artery protein kinase C (PKC) activity in rats with chronic inflammatory pulmonary hypertension (PHT).</p><p><b>METHODS</b>Chronic inflammatory PHT was induced in rats with monocrotaline. The PKC activities in the rat pulmonary arteries were measured by radioactive assay during the development of PHT.</p><p><b>RESULTS</b>With the development of chronic inflammatory PHT, the total and cytosolic fractions of PKC activity in PHT rat pulmonary arteries increased initially with subsequent decrease (Plt;0.05), but the membranous fraction of PKC activity and the membrane-to-cytosol PKC activity ratio increased continuously (P<0.05).</p><p><b>CONCLUSION</b>The up-regulation of PKC activity and the translocation of PKC might be associated with the development of chronic inflammatory PHT in rats.</p>