Microsatellite analysis and hMLH1/hMSH2 expression detection in young patients with colorectal cancer: value in screening hereditary nonpolyposis colorectal cancer / 南方医科大学学报
Journal of Southern Medical University
;
(12): 779-782, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-337386
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the frequency of microsatellite instability (MSI) and absence of hMLH1/hMSH2 expression in young patients with colorectal cancer, and investigate their role in screening hereditary nonpolyposis colorectal cancer (HNPCC).</p><p><b>METHOD</b>Seventy-three young patients (below 40 years old) with colorectal cancer were examined for DNA mismatch repair deficiency by microsatellite testing and immunohistochemical detection of hMLH1/hMSH2 gene products.</p><p><b>RESULTS</b>The frequency of MSI and absence rate of hMLH1/hMSH2 expression are 56.16% and 49.32% in these patients, respectively, which increased significantly with younger age for cancer diagnosis.</p><p><b>CONCLUSION</b>Defects in the DNA mismatch repair system are frequent in Chinese young patients with colorectal cancer. Microsatellite analysis and immunohistochemical detection are useful for efficient identification of HNPCC in these young patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Immunohistochemistry
/
Nuclear Proteins
/
Colorectal Neoplasms
/
Colorectal Neoplasms, Hereditary Nonpolyposis
/
Mass Screening
/
Microsatellite Repeats
/
Adaptor Proteins, Signal Transducing
/
Diagnosis
/
MutS Homolog 2 Protein
Type of study:
Diagnostic study
/
Screening study
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Journal of Southern Medical University
Year:
2007
Type:
Article
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