Research progress in hydroxylase in taxol biosynthetic pathway / 生物工程学报
Chinese Journal of Biotechnology
;
(12): 554-564, 2016.
Article
in Chinese
| WPRIM
| ID: wpr-337442
ABSTRACT
Taxol is a secondary metabolite with prominent anti-tumor activity, but the yield cannot meet the growing clinical demand due to lower content in yew. Now, most enzyme genes involved in taxol biosynthesis have been cloned and identified, so that obtaining this drug by using synthetic biology method has become a hotspot in recent years. However, most hydroxylases involved in taxol biosynthetic pathway have not been explored. Here, we reviewed the progress on the biosynthesis pathway of taxol, especially concerning hydroxylase. The future research areas of taxol biosynthesis through synthetic biology were also discussed to provide basis for the discovery of uncharacterized hydroxylase genes and the mass taxol production by synthetic biology technology.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Paclitaxel
/
Taxus
/
Biosynthetic Pathways
/
Synthetic Biology
/
Mixed Function Oxygenases
/
Metabolism
Language:
Chinese
Journal:
Chinese Journal of Biotechnology
Year:
2016
Type:
Article
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