Effect of tongmal recipe on atherosclerosis in patients with early lower extremity arteriopathy caused by type 2 diabetes mellitus / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 296-299, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-337519
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of Tongmai Recipe (TMR) on atherosclerosis (AS) in patients with early lower extremity arteriopathy disease (LEAD) caused by type 2 diabetes mellitus (T2DM).</p><p><b>METHODS</b>Patients were randomly assigned to two groups. The 23 patients in the treatment group were treated by TMR and the 22 in the control group were given Cilostazo, all for 3 months. Before and after treatment, lower extremity vascular color Doppler image, blood levels of glucose, insulin, serum matrix metalloproteinase-9 (MMP-9) and interleukin-6 (IL-6) were measured.</p><p><b>RESULTS</b>The thickness of AS plaque and that of arterial intima-media obviously reduced (P < 0.01 and P < 0.05), insulin sensitivity improved noticeably (P < 0.01), and serum levels of MMP-9 and IL-6 lowered obviously (P < 0.05) in the treatment group after treatment, but these indexes were unchanged in the control group statistically.</p><p><b>CONCLUSION</b>TMR has remarkable action in reducing the thickness of AS plaque and intima-media of artery, its mechanism might be related with improving of insulin sensitivity and anti-inflammatory reaction, and reducing of serum MMP-9 level as well in patients.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Arteriosclerosis
/
Blood
/
Insulin Resistance
/
Diagnostic Imaging
/
Drugs, Chinese Herbal
/
Ultrasonography
/
Interleukin-6
/
Tibial Arteries
/
Matrix Metalloproteinase 9
Type of study:
Diagnostic study
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2009
Type:
Article
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