Selective effect of nispex in inhibiting human cancer cell proliferation and inducing cell apoptosis / 中国中西医结合杂志
Chinese Journal of Integrated Traditional and Western Medicine
;
(12): 148-152, 2009.
Article
in Chinese
| WPRIM
| ID: wpr-337529
ABSTRACT
<p><b>OBJECTIVE</b>To observe the in vitro anticancer effect of Nispex, the total flavonoids extract from Scurrula parasitic L.</p><p><b>METHODS</b>The cell proliferation inhibitory effects of Nispex on various kinds of tumor cells or non-tumor cells in human and rats were detected with MTT assay and colony forming assay respectively, the cell apoptosis induced by Nispex was detected by AO/EB fluorescence staining, TUNEL assay and AnnexinV-FITC/PI flow cytometry.</p><p><b>RESULTS</b>Nispex could significantly inhibit human cancer cell proliferation and induce human cancer cell apoptosis, especially to the proliferative cell group, but its inhibition on human non-tumor cell was insignificant, and showed no effect on murine cancer cells in the tested scope.</p><p><b>CONCLUSION</b>Nispex is a nature plant extract which shows good selectivity for killing human cancer cell.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Pharmacology
/
Species Specificity
/
Flavonoids
/
Drugs, Chinese Herbal
/
Tumor Cells, Cultured
/
Chemistry
/
Apoptosis
/
Loranthaceae
/
Cell Proliferation
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Chinese Journal of Integrated Traditional and Western Medicine
Year:
2009
Type:
Article
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