Recent advance on blood group antigen modification of porcine erythrocytes / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 273-276, 2002.
Article
in Chinese
| WPRIM
| ID: wpr-337592
ABSTRACT
Advances in the field of xenotransplantation raise the intriguing possibility of using porcine red blood cells (pRBCs) as an alternative source for blood transfusion. Serologically, pRBCs share a number of characteristics with human red blood cells (RBCs), so pRBCs are considered the most likely donor for xenotransfusion. However, xenoantigens on porcine erythrocytes play major roles in antibody-mediated RBC destruction. Although the alphaGal epitope (Galalpha1, 3Galbeta1, 4GalNAc-R) is the major xenoantigen on porcine erythrocytes and is responsible for the binding of the majority of human natural antibodies, other non-alphaGal xenoantigens have been identified. The importance of these non-alphaGal xenoantigens in binding human natural antibodies and subsequently triggering immunological responses cannot be underestimated.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Swine
/
Transplantation, Heterologous
/
Blood Group Antigens
/
Erythrocyte Transfusion
/
Cell Biology
/
Allergy and Immunology
/
Erythrocytes
/
Methods
Type of study:
Prognostic study
Limits:
Animals
/
Humans
Language:
Chinese
Journal:
Journal of Experimental Hematology
Year:
2002
Type:
Article
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