Histopathologic Features and Immunophenotype of 19 Primary Cutaneous Lymphomas
Korean Journal of Pathology
;
: 1111-1119, 1999.
Article
in Korean
| WPRIM
| ID: wpr-33764
ABSTRACT
The diagnosis of primary cutaneous lymphoma is based on a combination of clinical, histological, immunophenotypic and genetic criteria. Nineteen cases of primary cutaneous lymphomas were studied for clinicopathologic, immunophenotypic, and genetic features. Seventeen (89%) cases were T cell origin and two cases (11%) were B cell origin. CD30-positive cutaneous lymphoproliferative disorder was the most frequent subtype, occupying 42% (8 cases) of the cases. CD8 was positive in 5 cases consisting of 3 cutaneous T cell lymphomas and 2 anaplastic large cell lymphomas. CD4 was positive in 2 cases of mycosis fungoides and 3 cases of lymphomatoid papulosis. Six (67%) of 9 cases of cutaneous T cell lymphoma were positive for TIA-1. Ten (83%) out of 12 cases showed clonal rearrangements of TCR gamma genes, however, one T/NK cell lymphoma and one anaplastic large cell lymphoma did not. EBV association was detected only in T/NK cell lymphomas among 10 cases examined. In conclusion, our study showed higher proportion of CD30-positive lymphoproliferative disorders and less frequent mycosis fungoides in Korea compared to the incidences in Western countries. Our immunostaining results suggested that mycosis fungoides and lymphomatoid papulosis are CD4-positive T cell origin, however, the remaining primary cutaneous T cell lymphoma is predominantly CD8-positive cytotoxic T cell origin.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Incidence
/
Lymphoma, T-Cell, Cutaneous
/
Mycosis Fungoides
/
Lymphomatoid Papulosis
/
Lymphoma, Large-Cell, Anaplastic
/
Herpesvirus 4, Human
/
Genes, T-Cell Receptor gamma
/
Diagnosis
/
Korea
/
Lymphoma
Type of study:
Diagnostic study
/
Incidence study
/
Prognostic study
Country/Region as subject:
Asia
Language:
Korean
Journal:
Korean Journal of Pathology
Year:
1999
Type:
Article
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