Interleukin-1β inhibits the amplitudes of voltage-gated Na(+) currents and action potential in cultured cortical neurons of rat / 生理学报
Acta Physiologica Sinica
;
(6): 131-137, 2011.
Article
in Chinese
| WPRIM
| ID: wpr-337694
ABSTRACT
Interleukin-1β (IL-1β) is an important proinflammatory cytokine and plays key roles in physiological and pathophysiological processes of central nervous system (CNS). The voltage-gated Na(+) channels are essential for electrical properties of excitable cells and control the excitability and action potential (AP) of neurons. Recent studies have showed the relationship between IL-1β and voltage-gated channels. In this work, cultured cortical neurons of rat were treated by 10 ng/mL of IL-1β for 24 h, and then voltage-gated Na(+) currents were recorded using voltage-clamp technique. The results indicated that IL-1β reduced the amplitude of Na(+) currents without any changes in activation or inactivation properties. The current-clamp recording showed that IL-1β reduced the amplitude of AP but not the threshold. These data indicate that IL-1β inhibits the voltage-gated Na(+) currents and the amplitude of AP, and suggest that essential roles of voltage-gated Na(+) channels may be changed by IL-1β. New information about effects of IL-1β on injuries and diseases of CNS was provided.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Physiology
/
Action Potentials
/
Cells, Cultured
/
Cerebral Cortex
/
Rats, Sprague-Dawley
/
Cell Biology
/
Interleukin-1beta
/
Voltage-Gated Sodium Channels
/
Neurons
Limits:
Animals
Language:
Chinese
Journal:
Acta Physiologica Sinica
Year:
2011
Type:
Article
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