Protective effects of omega-3 fish oil on lead-induced impairment of long-term potentiation in rat dentate gyrus in vivo / 生理学报
Acta Physiologica Sinica
;
(6): 225-230, 2010.
Article
in English
| WPRIM
| ID: wpr-337755
ABSTRACT
In order to evaluate the effect of omega-3 fish oil supplement by gavage (0.4 mL/100 g body weight) on the chronic lead-induced (0.2% lead acetate) impairments of long-term potentiation (LTP) in rat dentate gyrus (DG) in vivo, we designed the experiments which were carried out in four groups of newborn Wistar rats (the control, the lead-exposed, the control with fish oil treatment and the lead-exposed with fish oil treatment, respectively). The excitatory postsynaptic potential (EPSP) and population spike (PS) amplitude were measured in the DG of rats with above different treatments at the age of 80-90 d in response to stimulation applied to the lateral perforant path. The results showed (1) postnatal chronic lead-exposure impaired LTP measured on both EPSP slope and PS amplitude in DG area of the hippocampus; (2) in the control rats, omega-3 fish oil had no effect on LTP while in the lead-exposed rats, omega-3 fish oil had a protective effect on LTP. These results suggest that omega-3 fish oil supplement could protect rats from the lead-induced impairment of LTP. Omega-3 fish oil might be a preventive substance in reducing LTP deficits induced by lead.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Fish Oils
/
Fatty Acids, Omega-3
/
Chemistry
/
Rats, Wistar
/
Long-Term Potentiation
/
Dentate Gyrus
/
Perforant Pathway
/
Excitatory Postsynaptic Potentials
/
Lead Poisoning
Limits:
Animals
Language:
English
Journal:
Acta Physiologica Sinica
Year:
2010
Type:
Article
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