Coexistence of tuberous sclerosis complex and malignant melanoma
Singapore medical journal
;
: e233-5, 2013.
Article
in English
| WPRIM
| ID: wpr-337832
ABSTRACT
Tuberous sclerosis complex (TSC) is a multisystem genetic disorder characterised by widespread hamartomas in organs such as the skin, brain, heart, lung, liver and kidney. Although associations of TSC with hamartomas, angiomyolipomas and fibromas have been reported, there has been no report of its association with malignant melanoma. Herein, we describe a 31-year-old man with malignant melanoma associated with TSC. The patient had a history of epilepsia, multiple hypomelanotic macules, periungual fibromas and multiple hepatic lesions. Malignant melanoma was diagnosed by hepatic biopsy. To the best of our knowledge, this is the first report of malignant melanoma coexisting with TSC in the literature. We also present and discuss the imaging findings, prognosis, underlying mechanisms and practical approaches in relation to the disease.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Skin Neoplasms
/
Therapeutics
/
Tuberous Sclerosis
/
Biopsy, Needle
/
Immunohistochemistry
/
Magnetic Resonance Imaging
/
Tomography, X-Ray Computed
/
Follow-Up Studies
/
Risk Assessment
/
Rare Diseases
Type of study:
Diagnostic study
/
Etiology study
/
Observational study
/
Prognostic study
/
Risk factors
Limits:
Adult
/
Humans
/
Male
Language:
English
Journal:
Singapore medical journal
Year:
2013
Type:
Article
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