EML4-ALK Fusion Gene in Korean Non-Small Cell Lung Cancer
Journal of Korean Medical Science
; : 228-230, 2012.
Article
in En
| WPRIM
| ID: wpr-33788
Responsible library:
WPRO
ABSTRACT
A fusion gene between echinoderm microtubule-associated protein-like 4 (EML4) and the anaplastic lymphoma kinase (ALK) has been identified in non-small cell lung cancers (NSCLCs). Although a few studies have evaluated EML4-ALK fusion genes in Korean NSCLCs, the prevalence of different EML4-ALK fusion variants has yet to be clearly assessed. Herein, we have examined the profiles of EML4-ALK fusion gene variants in Korean patients of NSCLCs. EML4-ALK fusion genes have been detected in 10 (6.0%) of 167 patients of NSCLCs and in 9 (7.4%) of 121 patients of adenocarcinoma. Of the 10 patients with fusion genes identified, 8 (80%) were E13;A20 (variant 1) and 2 (20%) were E6;A20, with an additional 33-bp sequence derived from intron 6 of EML4 (variant 3b). These results indicate that the profiles of EML4-ALK fusion gene variants in Korean patients of NSCLC may differ from those in other ethnic populations. Herein, we describe for the first time the profiles of EML4-ALK fusion variants of Korean patients with NSCLCs.
Key words
Full text:
1
Index:
WPRIM
Main subject:
Base Sequence
/
Introns
/
Adenocarcinoma
/
Smoking
/
Oncogene Proteins, Fusion
/
Exons
/
Sequence Analysis, RNA
/
Carcinoma, Non-Small-Cell Lung
/
Asian People
/
Republic of Korea
Type of study:
Prognostic_studies
Limits:
Aged
/
Female
/
Humans
/
Male
Country/Region as subject:
Asia
Language:
En
Journal:
Journal of Korean Medical Science
Year:
2012
Type:
Article