Effect of aralosides to contraction function and calcium transient of ischemia/reperfusion myocardial cells / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2403-2407, 2015.
Article
in Chinese
| WPRIM
| ID: wpr-337921
ABSTRACT
To discuss the protective effect of aralosides (AS) on I/R-induced rat myocardial injury. The adult rat ventricular myocyte ischemia model was established through perfusion with sodium lactate perfusate and reperfusion with Ca(2+) -containing Tyrode's solution simulation. The cell contraction and ion concentration synchronization determination system was applied to detect the effect of AS on single I/R cell contraction and Ca2+ transients. According to the findings, AS could increase resting sarcomere length, contraction amplitude, ± dL/dt(max), calcium transient amplitude and speed of post-reperfusion myocardial cells (P < 0.05, P < 0.01), and decrease in time for achieving 90.0% of maximum relaxation, time for achieving peak value, resting calcium ratio, contraction period [Ca2+] i, time for achieving 50.0% of maximum relaxation and attenuation rate of intracellular calcium transient (P < 0.05, P < 0.01). Therefore, it is suggested that AS improved the post-reperfusion cell contraction and injury of calcium homeostasis.
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Physiology
/
Saponins
/
General Surgery
/
Biological Transport
/
Drugs, Chinese Herbal
/
Myocardial Reperfusion
/
Chemistry
/
Calcium
/
Rats, Sprague-Dawley
/
Myocardial Ischemia
Type of study:
Prognostic study
Limits:
Animals
/
Humans
/
Male
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2015
Type:
Article
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