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Secondary metabolites from a deep-sea-derived actinomycete Micrococcus sp. R21 / 中国中药杂志
China Journal of Chinese Materia Medica ; (24): 2367-2371, 2015.
Article in Chinese | WPRIM | ID: wpr-337927
ABSTRACT
To investigate cytotoxic secondary metabolites of Micrococcus sp. R21, an actinomycete isolated from a deep-sea sediment (-6 310 m; 142 degrees 19. 9' E, 10 degrees 54. 6' N) of the Western Pacific Ocean, column chromatography was introduced over silica gel, ODS, and Sephadex LH-20. As a result, eight compounds were obtained. By mainly detailed analysis of the NMR data, their structures were elucidated as cyclo(4-hydroxy-L-Pro-L-leu) (1), cyclo(L-Pro-L-Gly) (2), cyclo( L-Pro-L-Ala) (3), cyclo( D-Pro-L-Leu) (4), N-β-acetyltryptamine (5), 2-hydroxybenzoic acid (6), and phenylacetic acid (7). Compound 1 exhibited weak cytotoxic activity against RAW264. 7 cells with IC50 value of 9.1 μmol x L(-1).
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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Phylogeny / Seawater / Mass Spectrometry / Magnetic Resonance Spectroscopy / Molecular Structure / Biological Factors / Cell Survival / Chemistry / Cell Biology Limits: Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2015 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Pharmacology / Phylogeny / Seawater / Mass Spectrometry / Magnetic Resonance Spectroscopy / Molecular Structure / Biological Factors / Cell Survival / Chemistry / Cell Biology Limits: Animals Language: Chinese Journal: China Journal of Chinese Materia Medica Year: 2015 Type: Article