Studies on sustained release solid dispersion of tripterine carried by HPMC-stearic acid / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 3052-3055, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-337994
ABSTRACT
<p><b>OBJECTIVE</b>To prepare the sustained release solid dispersion of tripterine, using HPMC-stearic acid with the intention of improving drug dissolution and controlling drug releases moderate, so that the drug performances lower toxicity.</p><p><b>METHOD</b>Tripterine sustained release solid dispersions was prepared by the solvent method with different weight ratios of HPMC-stearic acid and tripterine, which were dissolved in 95% ethanol. And in vitro dissolution experiment was conducted. Differential scanning calorimetry, scanning electron microscopy and X-ray powder diffraction can prove the formation of solid dispersions.</p><p><b>RESULT</b>The ideal tripterine sustained release solid dispersions were prepared under the condition as follows, the weight ratio of tripterine and HPMC-stearic acid was 1 10, and the release rate of drug can keep moderate and controllable. In vitro cumulative release of tripterine sustained release solid dispersion is up to more than 90% after 8 h, and the tripterine exist as amorphous in the solid dispersion.</p><p><b>CONCLUSION</b>The sustained release solid dispersion of tripterine, carried by HPMC-stearic acid, can improve the release of tripterine effectively and controls the release rate keep moderate and controllable, and the preparation process is simple, which has potential applications.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Stearic Acids
/
Triterpenes
/
Drug Carriers
/
Kinetics
/
Chemistry
/
Chemistry, Pharmaceutical
/
Delayed-Action Preparations
/
Methods
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2012
Type:
Article
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