Meta-analysis of Shenmai injection treatment for acute myocardial infarction / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 2760-2767, 2012.
Article
in Chinese
| WPRIM
| ID: wpr-338022
ABSTRACT
<p><b>OBJECTIVE</b>To assess the efficacy and safety of Shenmai injection for acute myocardial infarction (AMI).</p><p><b>METHOD</b>All clinical studies of Shenmai for AMI were searched from Cochrane library, Medline, EMbase, CBM, CNKI, Wanfang and VIP. For efficacy analysis of Shenmai, randomized controlled trials (RCTs) and quasi-RCTs were included and the Cochrane Collaboration's RevMan 5.1 was used for data analysis.</p><p><b>RESULT</b>1) Fifty studies were included for efficacy analysis, in which, only 1 study was true RCT, all of studies did not mention allocation concealment, blind and information of loss to follow-up. The fatality rate during hospitalization (OR 0.43, 95% CI [0.31-0.60]), incidence of heart failure (OR 0.49, 95% CI [0.34-0.70]), incidence of shock (OR 0.53, 95% CI[0.30-0.93]) and incidence of re-infarction (OR 0.16, 95% CI [0.03-0.77]) in Shenmai injection plus conventional treatment group was lower than that in the conventional treatment group, while the rate of recanalization (OR 1.24, 95% CI [0.90-1.71]) was similar between the two groups. 2) For safety analysis, we did not found serious adverse drug reaction/adverse events (ADR/AE) of Shenmai injection for AMI.</p><p><b>CONCLUSION</b>The currently available evidence showed that Shenmai injection plus conventional treatment group may decrease the fatality rate during hospitalization, the incidence of cardiac failure, shock and re-infarction. However, these findings should be carefully interpreted due to the low methodological quality and small sample size of trials. Although serious ADR/AE was did not report of Shenmai injection, the post-marketing safety evaluation is need to be performed.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Drugs, Chinese Herbal
/
Randomized Controlled Trials as Topic
/
Mortality
/
Treatment Outcome
/
Therapeutic Uses
/
Drug Combinations
/
Drug Therapy
/
Myocardial Infarction
Type of study:
Controlled clinical trial
/
Prognostic study
/
Systematic reviews
Limits:
Adolescent
/
Adult
/
Aged
/
Child
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
China Journal of Chinese Materia Medica
Year:
2012
Type:
Article
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