Effect of hepatitis C virus core protein on cholangiocarcinoma tissues' epithelial-mesenchymal transition / 中华外科杂志
Chinese Journal of Surgery
;
(12): 1491-1493, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-338125
ABSTRACT
<p><b>OBJECTIVE</b>To explore the role of hepatitis C virus core protein on the infiltration and metastasis of cholangiocarcinoma tissues.</p><p><b>METHODS</b>From January 2001 to November 2006, 34 patients with cholangiocarcinoma who had intact follow-up data randomly were chosen. The expression of HCVc protein, epithelium markers and mesenchymal markers in cholangiocarcinoma tissues were examined by SP methods of immunohistochemistry, clinical-pathological data were recorded and analyzed.</p><p><b>RESULTS</b>The positive expression rate was observed in 47.1% for HCVc protein, 50% for N-cadherin, 44.1% for Vimentin, 55.9% for Fibronectin and the decreased expression rate was E-cadherin for 55.9%, alpha-catenin for 70.6%, beta-catenin for 55.9%. The positive expression of HCVc protein was associated with the decreased expression of E-cadherin, alpha-catenin and the positive expression of N-cadherin, Vimentin, Fibronectin (chi(2) = 4.480, 4.163, 4.250, 7.438, 12.260, P < 0.05). A positive-correlation between the expression of HCVc protein and metastasis of lymph nodes and other organs were found (chi(2) = 5.708, 4.163, P < 0.05).</p><p><b>CONCLUSION</b>HCVc protein might promote cholangiocarcinoma tissues' infiltration and metastasis by inducing it's epithelial-mesenchymal transition.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Physiology
/
Virology
/
Immunohistochemistry
/
Cell Transformation, Neoplastic
/
Viral Core Proteins
/
Hepatitis C
/
Cholangiocarcinoma
/
Hepacivirus
/
Epithelium
Limits:
Adult
/
Aged
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2007
Type:
Article
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