Significance of changes in plasma bactericidal/permeability-increasing protein levels in patients with severe surgical infection / 中华外科杂志
Chinese Journal of Surgery
;
(12): 1342-1345, 2007.
Article
in Chinese
| WPRIM
| ID: wpr-338160
ABSTRACT
<p><b>OBJECTIVE</b>To investigate changes in endogenous bactericidal/permeability-increasing protein (BPI) levels and their significance in patients with surgical sepsis.</p><p><b>METHODS</b>In the prospective study, 19 surgical patients with infection were involved. The plasma BPI, lipopolysaccharide-binding protein (LBP) and interleukin-6 levels were measured on post-infected days 1, 3, 5, 7 and 14 by an enzyme-linked immunosorbent assay (ELISA). Plasma endotoxin concentrations were determined by the modified chromogenic Limulus Amebocyte Lysate (LAL).</p><p><b>RESULTS</b>Compared with normal controls, significant lower plasma BPI/LBP ratios were observed in septic patients on days 1 to 5 after infection (P < 0.01), and in severe septic patients on days 1 to 7 (P < 0.01). Moreover, plasma BPI/LBP ratios were much lower in severe sepsis than those in sepsis on days 1 to 3 after infection (P < 0.05).</p><p><b>CONCLUSIONS</b>Plasma BPI and LBP levels increased rapidly after infection, but BPI/LBP ratios were significantly decreased during sepsis. Plasma BPI/LBP ratios appear to be closely related to the severity of sepsis in patients complicated by surgical infection.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Postoperative Complications
/
Prognosis
/
Blood
/
Acute-Phase Proteins
/
Enzyme-Linked Immunosorbent Assay
/
Membrane Glycoproteins
/
Blood Proteins
/
Carrier Proteins
/
Prospective Studies
/
Interleukin-6
Type of study:
Observational study
/
Prognostic study
Limits:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
Language:
Chinese
Journal:
Chinese Journal of Surgery
Year:
2007
Type:
Article
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