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Significance of changes in plasma bactericidal/permeability-increasing protein levels in patients with severe surgical infection / 中华外科杂志
Chinese Journal of Surgery ; (12): 1342-1345, 2007.
Article in Chinese | WPRIM | ID: wpr-338160
Responsible library: WPRO
ABSTRACT
<p><b>OBJECTIVE</b>To investigate changes in endogenous bactericidal/permeability-increasing protein (BPI) levels and their significance in patients with surgical sepsis.</p><p><b>METHODS</b>In the prospective study, 19 surgical patients with infection were involved. The plasma BPI, lipopolysaccharide-binding protein (LBP) and interleukin-6 levels were measured on post-infected days 1, 3, 5, 7 and 14 by an enzyme-linked immunosorbent assay (ELISA). Plasma endotoxin concentrations were determined by the modified chromogenic Limulus Amebocyte Lysate (LAL).</p><p><b>RESULTS</b>Compared with normal controls, significant lower plasma BPI/LBP ratios were observed in septic patients on days 1 to 5 after infection (P < 0.01), and in severe septic patients on days 1 to 7 (P < 0.01). Moreover, plasma BPI/LBP ratios were much lower in severe sepsis than those in sepsis on days 1 to 3 after infection (P < 0.05).</p><p><b>CONCLUSIONS</b>Plasma BPI and LBP levels increased rapidly after infection, but BPI/LBP ratios were significantly decreased during sepsis. Plasma BPI/LBP ratios appear to be closely related to the severity of sepsis in patients complicated by surgical infection.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Postoperative Complications / Prognosis / Blood / Female / Humans / Male / Acute-Phase Proteins / Enzyme-Linked Immunosorbent Assay / Membrane Glycoproteins / Blood Proteins Language: Chinese Journal: Chinese Journal of Surgery Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Postoperative Complications / Prognosis / Blood / Female / Humans / Male / Acute-Phase Proteins / Enzyme-Linked Immunosorbent Assay / Membrane Glycoproteins / Blood Proteins Language: Chinese Journal: Chinese Journal of Surgery Year: 2007 Type: Article