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Micro-CT evaluation and histological analysis of screw-bone interface of expansile pedicle screw in osteoporotic sheep / 中华外科杂志
Chinese Journal of Surgery ; (12): 1271-1273, 2007.
Article in Chinese | WPRIM | ID: wpr-338175
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the properties of screw-bone interface of expansive pedicle screw (EPS) in osteoporotic sheep using micro-CT and histology.</p><p><b>METHODS</b>Six female sheep with bilateral ovariectomy-induced osteoporosis were employed in this experiment and were randomly assigned into 2 groups A and B. After EPS insertion in each femoral condyles, sheep in group A were bred for 3 months, while those in group B 6 months. Femoral condyles with EPS were 3D-imaged and reconstructed by micro-CT. Histology was evaluated thereafter.</p><p><b>RESULTS</b>The trabecular microstructure was denser at the screw-bone interface than in the distant parts in expansive section, especially within spiral marking. In the non-expansive section, however, there was no significant difference between the interface and the distant parts. The regions of interest (ROI) adjacent to EPS were reconstructed and analyzed by micro-CT using the same thresholds. The 3D-parameters generated, including tissue mineral density (TMD), bone volume fraction (BVF, BV/TV), bone surface/bone volume (BS/BV) ratio, trabecular thickness (Tb.Th), and trabecular separation (Tb.Sp), were significantly better in expansive than in non-expansive sections (P < 0.05). Histologically, newly formed bone trabeculae crawled along the expansive fissures and into the center of EPS. The newly formed bones, as well as the bone at the bone-screw interface, closely contacted the EPS and constructed four compartments.</p><p><b>CONCLUSIONS</b>Based on micro-CT and histological evaluation, the study suggest that EPS can significantly provide stabilization in osteoporotic cancellous bone.</p>
Subject(s)
Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteoporosis / Pathology / General Surgery / Bone Screws / Sheep / Diagnostic Imaging / Ovariectomy / Tomography, X-Ray Computed / Bone Density / Reproducibility of Results Type of study: Diagnostic study / Prognostic study Limits: Animals Language: Chinese Journal: Chinese Journal of Surgery Year: 2007 Type: Article

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Full text: Available Index: WPRIM (Western Pacific) Main subject: Osteoporosis / Pathology / General Surgery / Bone Screws / Sheep / Diagnostic Imaging / Ovariectomy / Tomography, X-Ray Computed / Bone Density / Reproducibility of Results Type of study: Diagnostic study / Prognostic study Limits: Animals Language: Chinese Journal: Chinese Journal of Surgery Year: 2007 Type: Article