Effect of intra-testicular testosterone withdrawal on the expression of alpha-catenin in the adult rat testis / 中华男科学杂志
National Journal of Andrology
;
(12): 394-400, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-338286
ABSTRACT
<p><b>OBJECTIVE</b>To study the expression of alpha-catenin in the rat testis after intra-testicular testosterone withdrawal induced by injection of testosterone undecanoate (TU).</p><p><b>METHODS</b>Ten adult male SD rats received vehicle (n = 5 ) or TU (19 mg/kg every 15 days, n = 5) for 130 days. Paraffin-embedded testicular sections were used for immunohistochemistry against a polyclonal anti-alpha-catenin antibody.</p><p><b>RESULTS</b>In the control, alpha-catenin was expressed in the acrosome of spermatids and the cytoplasm of Leydig cells and peritubular myoid cells. In the TU-treated rat testis, Leydig cells were atrophied and the expression of alpha-catenin was markedly decreased or absent, but there was no evident change in the immunostaining of spermatids or myoid cells.</p><p><b>CONCLUSION</b>Intra-testicular testosterone withdrawal-induced looser arrangement or sloughing of spermatogenic cells is not related to the adhesion molecule alpha-catenin. Alpha-catenin may be used as a cell identification marker for Leydig cells.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pharmacology
/
Testis
/
Testosterone
/
Immunohistochemistry
/
Rats, Sprague-Dawley
/
Alpha Catenin
/
Leydig Cells
/
Metabolism
Limits:
Animals
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2006
Type:
Article
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