Expression and significance of survivin protein, PTEN in prostatic cancer / 中华男科学杂志
National Journal of Andrology
;
(12): 346-351, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-338295
ABSTRACT
<p><b>OBJECTIVE</b>To study the expressions of survivin, PTEN and their relationships with tissue grade and pathology stage in prostatic carcinoma (PCa).</p><p><b>METHODS</b>The immunohistological staining was used to evaluated the expressions of survivin protein and PTEN in 43 case of prostatic carcinoma (PCa) and 5 cases of benign prostatic hyperplasia (BPH).</p><p><b>RESULTS</b>The positive rate of survivin protein was 81.40%. Expression of survivin protein in 5 case of BPH was negative. The positive rate of PTEN was 30.23%, and the higher the grade and the clinical stage of tumors were, the lower the expression of PTEN was, PTEN of 5 case of BPH was positive.</p><p><b>CONCLUSION</b>The positively correlation was found between the abnormal expressions of survivin protein, PTEN and the biological behavior of prostatic carcinoma (PCa). Detection of survivin combined with PTEN is valuable for diagnosing PCa, and evaluating malignancy extent and prognosis.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Prostatic Neoplasms
/
Immunohistochemistry
/
PTEN Phosphohydrolase
/
Inhibitor of Apoptosis Proteins
/
Metabolism
/
Microtubule-Associated Proteins
/
Neoplasm Proteins
Type of study:
Prognostic study
Limits:
Aged
/
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2006
Type:
Article
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