Expression and implication of cyclooxygenase-2 mRNA in prostate cancer / 中华男科学杂志
National Journal of Andrology
;
(12): 159-161, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-338340
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the relationship between cyclooxygenase-2 (COX-2) mRNA expression and the biological behaviors of prostate carcinoma (PCa).</p><p><b>METHODS</b>The expression of COX-2 mRNA was detected by RT-PCR method in 32 samples of PCa and the COX-2/GAPDH value was determined. Seven normal prostate tissues were served as control.</p><p><b>RESULTS</b>The expression of COX-2 mRNA in normal tissue of 7 control cases was all negative. There was statistical correlation between the COX-2/GAPDH and the Gleason scores of PCa. There also showed statistical correlation between the COX-2/GAPDH and the stages of PCa.</p><p><b>CONCLUSION</b>COX-2 mRNA play an important role in occurrence and progression of the PCa. COX-2 is a tumor marker which may be the possible prognostic factor of PCa.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Pathology
/
Prognosis
/
Prostate
/
Prostatic Neoplasms
/
RNA, Messenger
/
Case-Control Studies
/
Reverse Transcriptase Polymerase Chain Reaction
/
Cyclooxygenase 2
/
Genetics
/
Metabolism
Type of study:
Observational study
/
Prognostic study
Limits:
Adult
/
Aged
/
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2006
Type:
Article
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