Promotor hypermethylation of E-cadherin, p16 and estrogen receptor in prostate carcinoma / 中华男科学杂志
National Journal of Andrology
;
(12): 28-31, 2006.
Article
in Chinese
| WPRIM
| ID: wpr-338375
ABSTRACT
<p><b>OBJECTIVE</b>To investigate promotor hypermethylation of the CpG islands of E-Cadherin, p16 and estrogen receptor (ER) in prostate carcinoma and explore whether such methylation might play a role in the tumorigenesis and malignant progression of prostate carcinoma and their significance in the diagnosis, prognosis and treatment.</p><p><b>METHODS</b>Thirteen specimens of benign prostatic hypertrophy (BPH), 10 specimens of high grade prostate intraepithelial neoplasia (HGPIN) and 20 specimens of prostate carcinoma (with follow-up records) were collected from the patients who underwent radical prostatectomy or transurethral resection. Methylation-specific PCR (MSP) was used to detect the promoter hypermethylation of E-Cadherin, p16 and ER genes.</p><p><b>RESULTS</b>Hypermethylation percentages in prostate carcinoma were E-Cadherin, 30%; p16, 25%; and ER, 65%. Almost all nonmalignant tissues (BPH and HG-PIN) lacked methylation of any genes.</p><p><b>CONCLUSION</b>Detecting promotor hypermethylation of E-Cadherin, p16 and ER may be helpful to differentiate nonmalignant lesions from prostate carcinoma.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Prostatic Neoplasms
/
Receptors, Estrogen
/
Cadherins
/
Polymerase Chain Reaction
/
Promoter Regions, Genetic
/
Prostatic Intraepithelial Neoplasia
/
CpG Islands
/
DNA Methylation
/
Genes, p16
/
Genetics
Limits:
Aged
/
Aged80
/
Humans
/
Male
Language:
Chinese
Journal:
National Journal of Andrology
Year:
2006
Type:
Article
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