Association of tag SNPs of GPx-3 with essential hypertension in rural Han Chinese in Fuxin, Liaoning, China / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 2113-2116, 2011.
Article
in English
| WPRIM
| ID: wpr-338503
ABSTRACT
<p><b>BACKGROUND</b>Genetic mechanisms contribute to blood pressure regulation. This study investigated whether glutathione peroxidase (GPx-3) tag single nucleotide polymorphisms (SNPs) are associated with hypertension in the rural areas of Fuxin county, Liaoning province, China.</p><p><b>METHODS</b>Indigenous Fuxin Han people participated, 523 unrelated hypertensives and 547 controls were recruited. All tag SNPs of GPx-3 gene were selected. We estimated SNP allele frequency in DNA pools with pyrosequencing.</p><p><b>RESULTS</b>Before Bonferroni correction, C allele frequency for rs8177417 was significantly higher in hypertensives than those in controls (23.4% vs. 19.3%, P = 0.014); T allele frequency for rs3828599 was significantly lower in hypertensives than those in controls (35.6% vs. 40.8%, P = 0.009). However, when a Bonferroni correction for multiple testing was applied, only the polymorphisms rs3828599 of GPx-3 gene was associated with hypertension (P = 0.045, OR 0.833, 95%CI 0.695 - 0.998).</p><p><b>CONCLUSION</b>The polymorphism of rs3828599 of GPx-3 gene might be associated with hypertension in rural Han Chinese from Fuxin, Liaoning.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Genetic Predisposition to Disease
/
Polymorphism, Single Nucleotide
/
Gene Frequency
/
Genetics
/
Glutathione Peroxidase
/
Hypertension
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Medical Journal
Year:
2011
Type:
Article
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