Diagnosis of colon cancer with Fourier transform infrared spectroscopy on the malignant colon tissue samples / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 2517-2521, 2011.
Article
in English
| WPRIM
| ID: wpr-338516
ABSTRACT
<p><b>BACKGROUND</b>Fourier transform infrared spectroscopy (FT-IR) combined with chemometrics discriminant analysis technology could improve diagnosis. The present study aimed to evaluate the effects of FT-IR on malignant colon tissue samples in diagnosis of colon cancer.</p><p><b>METHODS</b>Principal component analysis (PCA) and support vector machine classification were used to discriminate FT-IR spectra from malignant and normal tissue. Colon tissues samples from 85 patients were used to demonstrate the procedure.</p><p><b>RESULTS</b>For this set of colon spectral data, the sensitivity and specificity of the support vector machine (SVM) classification were found both higher than 90%.</p><p><b>CONCLUSIONS</b>FT-IR provided important information about cancerous tissue, which could be used to discriminate malignant from normal tissues. The combination of PCA and SVM classification indicated that FT-IR has a potential clinical application in diagnosis of colon cancer.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Sensitivity and Specificity
/
Spectroscopy, Fourier Transform Infrared
/
Colonic Neoplasms
/
Principal Component Analysis
/
Diagnosis
/
Support Vector Machine
/
Methods
Type of study:
Diagnostic study
Limits:
Aged
/
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Medical Journal
Year:
2011
Type:
Article
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