Effects of mild hypothermia on patients with lower intracranial pressure following severe brain injury / 中华创伤杂志(英文版)
Chinese Journal of Traumatology
;
(6): 54-56, 2005.
Article
in English
| WPRIM
| ID: wpr-338644
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of mild hypothermia therapy on severe brain-injured patients whose intracranial pressure (ICP) could be maintained below 25 mm Hg.</p><p><b>METHODS</b>Forty severe brain-injured patients with ICP below 25 mm Hg were divided randomly into one treatment group (n=20, mild hypothermia therapy) and one control group (n=20, normothermia therapy) to observe the changes of the concentration of excitatory amino acids (glutamate and glycine) and cytokines (interleukin-1beta and interleukin-6).</p><p><b>RESULTS</b>There were no significant differences in the daily changes of the concentration of excitatory amino acid and cytokines between two groups. The outcome of two groups had no significant differences.</p><p><b>CONCLUSIONS</b>Mild hypothermia has no additional beneficial effects on severe brain-injured patients compared with normothermia therapy if ICP can be maintained below 25 mm Hg by using conventional therapy.</p>
Full text:
Available
Index:
WPRIM (Western Pacific)
Main subject:
Therapeutics
/
Enzyme-Linked Immunosorbent Assay
/
Intracranial Pressure
/
Chi-Square Distribution
/
Glasgow Coma Scale
/
Cerebrospinal Fluid
/
Analysis of Variance
/
Treatment Outcome
/
Craniocerebral Trauma
/
Hypothermia, Induced
Limits:
Female
/
Humans
/
Male
Language:
English
Journal:
Chinese Journal of Traumatology
Year:
2005
Type:
Article
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